GW837016X

GW837016X (NEU-391) is an orally active ErbB-2 kinase covalent inhibitor. GW837016X also is a potent antitrypanosome agent. GW837016X inhibits mitosis and cytokinesis[1].

Product Specifications

CAS Number

[833473-68-0]

Product Name Alternative

NEU-391

UNSPSC

12352005

Target

EGFR; Mitosis; Paraptosis

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gw837016x.html

Smiles

FC1=CC(COC2=CC=C(NC3=C4C(C=C(C#C[C@H]5NCCC5)S4)=NC=N3)C=C2Cl)=CC=C1

Molecular Formula

C25H20ClFN4OS

Molecular Weight

478.97

References & Citations

[1]Woodring JL, et al. Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation. ACS Med Chem Lett. 2018 Sep 4;9 (10) :996-1001.