Rohinitib

Rohinitib is a potent and specific eIF4A inhibitor. Rohinitib induces cell apoptosis of acute myeloid leukemia (AML) cell lines and reduces the leukemia burden of AML xenograft model. Rohinitib can be used for the research of AML[1].

Product Specifications

CAS Number

[1139253-73-8]

UNSPSC

12352005

Target

Apoptosis; Eukaryotic Initiation Factor (eIF)

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rohinitib.html

Purity

99.87

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

COC1=CC=C([C@@]23OC4=CC(OC)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(N(OC)C)=O)O)C=C1

Molecular Formula

C29H31NO8

Molecular Weight

521.56

References & Citations

[1]Nishida Y, et alJ. Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML. Leukemia. 2021 Sep;35 (9) :2469-2481.