Rohinitib
Rohinitib is a potent and specific eIF4A inhibitor. Rohinitib induces cell apoptosis of acute myeloid leukemia (AML) cell lines and reduces the leukemia burden of AML xenograft model. Rohinitib can be used for the research of AML[1].
Product Specifications
CAS Number
1139253-73-8
UNSPSC
12352005
Target
Apoptosis; Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rohinitib.html
Purity
99.87
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
COC1=CC=C([C@@]23OC4=CC(OC)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(N(OC)C)=O)O)C=C1
Molecular Formula
C29H31NO8
Molecular Weight
521.56
References & Citations
[1]Nishida Y, et alJ. Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML. Leukemia. 2021 Sep;35 (9) :2469-2481.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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