Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Angstrom6

Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling[1][2].

Product Specifications

CAS Number

[220334-14-5]

Product Name Alternative

A6 Peptide

UNSPSC

12352209

Target

PAI-1

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/angstrom6.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(N(CCC1)[C@@H]1C(N[C@@H](CCC(O)=O)C(N[C@H](C(N)=O)CCC(O)=O)=O)=O)[C@H](CCC2)N2C([C@H](CO)NC([C@H](CO)NC([C@H](CCC3)N3C([C@@H](NC(C)=O)CCCCN)=O)=O)=O)=O

Molecular Formula

C39H62N10O15

Molecular Weight

910.97

References & Citations

[1]Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 2008;111 (1) :89-94.|[2]Finlayson M. Modulation of CD44 Activity by A6-Peptide. Front Immunol. 2015;6:135. Published 2015 Mar 30.|[3]Piotrowicz RS, et al. A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells. Mol Cancer Ther. 2011;10 (11) :2072-2082.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P2230/Angstrom6-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P2230/Angstrom6-SDS-MedChemExpress.pdf

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

CALR Recombinant Protein
OPCD02436-50UG 50 µg

CALR Recombinant Protein

Ask
View Details
Vimentin (Phospho-Ser83) Colorimetric Cell-Based ELISA Kit
EKC2342 1 Kit - Containing Two 96 Well Plates & All Necessary Reagents

Vimentin (Phospho-Ser83) Colorimetric Cell-Based ELISA Kit

Ask
View Details
Recombinant Human FKBP2 (C-6His)
PHH0669-01 10 µg

Recombinant Human FKBP2 (C-6His)

Ask
View Details
Recombinant Human FKBP2 (C-6His)
PHH0669-02 50 µg

Recombinant Human FKBP2 (C-6His)

Ask
View Details
Recombinant Human FKBP2 (C-6His)
PHH0669-03 500 µg

Recombinant Human FKBP2 (C-6His)

Ask
View Details
Iqcg (NM_178378) Mouse Tagged ORF Clone Lentiviral Particle
MR206635L3V 200 µL

Iqcg (NM_178378) Mouse Tagged ORF Clone Lentiviral Particle

Ask
View Details