What is the catalog number for MPTP (hydrochloride)?

The catalog number for MPTP (hydrochloride) is HY-15608.

What sizes are available for MPTP (hydrochloride)?

MPTP (hydrochloride) is available in the following size(s): 5 mg, 10 mg, 10 mM - 1 mL, 50 mg, 100 mg, 200 mg, 500 mg, 1 g.

How many pack sizes does MPTP (hydrochloride) come in?

MPTP (hydrochloride) is available in 8 different pack sizes.

Is MPTP (hydrochloride) in stock?

MPTP (hydrochloride) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MPTP (hydrochloride)?

MPTP (hydrochloride) is manufactured by QuantiMol.

What is the estimated delivery time for MPTP (hydrochloride)?

Estimated delivery time for MPTP (hydrochloride) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for MPTP (hydrochloride)?

The safety data sheet for MPTP (hydrochloride) is available here: http://file.medchemexpress.com/batch_PDF/HY-15608/MPTP-hydrochloride-SDS-MedChemExpress.pdf.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

MPTP (hydrochloride)

MPTP hydrochloride is a brain penetrant dopaminergic neurotoxin. MPTP hydrochloride can be used to induce Parkinson’s Disease model. MPTP hydrochloride, a precusor of MPP+, induces apoptosis[1][2][3]. MPTP hydrochloride has been verified by MCE with professional biological experiments.

Product Specifications

CAS Number

23007-85-4

UNSPSC

12352005

Hazard Statement

H301+H311+H331, H315, H319, H335

Target

Apoptosis; Dopamine Receptor

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/MPTP-hydrochloride.html

Purity

99.91

Solubility

DMSO : 12 mg/mL (ultrasonic; warming) |H2O : ≥ 100 mg/mL

Smiles

CN1CC=C(C2=CC=CC=C2)CC1.[H]Cl

Molecular Formula

C12H16ClN

Molecular Weight

209.72

Precautions

H301+H311+H331, H315, H319, H335

References & Citations

[1]Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question) . Life Sci., 1985, 36, No. 3, 201-12.|[2]Hsu K S, et al. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83.|[3]Sun XL, et al. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models. J Neuroinflammation. 2016 Jul 8;13 (1) :180.|[4]Jackson-Lewis V, Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc. 2007;2 (1) :141-51.|[5]Rabaneda-Lombarte N, et al. The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease. J Neuroinflammation. 2021 Apr 6;18 (1) :88. |[6]Lee, et al. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell Death Differ. 2019 Jan;26 (2) :213-228.|[7]Zhang QS, et al. Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease. Acta Pharmacol Sin. 2017 Oct;38 (10) :1317-1328.|[8]Hammock BD, et al., A sheep model for MPTP induced Parkinson-like symptoms. Life Sci. 1989;45 (17) :1601-8.|[9]Ren J, et al. Time association study on a sub-acute mouse model of Parkinson's disease. Heliyon. 2024 Jul 4;10 (13) :e34082.