Pooled Microsomes from Liver

<strong>Pooled Microsomes from Liver</strong>_x000D_ <strong>Catalog number:</strong> B2016589_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 vial_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −80°C_x000D_ <strong>Keywords:</strong> Microsomes from Liver, Pooled_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Joseph D, Lesueur C, Zerizer F, Fenot A, Alvarez JC, Larabi IA. Characterization of extensive 2-fluorodeschloroketamine metabolism in pooled human liver microsomes, urine and hair from an addicted patient using high-resolution accurate mass spectrometry J Anal Toxicol. 2023 Jul 22;47(6):504-516._x000D_ 2: Ramsden D, Perloff ES, Whitcher-Johnstone A, Ho T, Patel R, Kozminski KD, Fullenwider CL, Zhang JG. Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model Drug Metab Dispos. 2022 Feb;50(2):114-127._x000D_ 3: Lehmler HJ, Uwimana E, Dean LE, Kovalchuk N, Zhang QY, Ding X. Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using Liver Microsomes from Transgenic Mouse Models Chem Res Toxicol. 2022 Dec 19;35(12):2310-2323._x000D_ 4: Yeung JH, Or PM. Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes Phytomedicine. 2011 Oct 15;18(13):1170-5._x000D_ 5: Gaunitz F, Dahm P, Mogler L, Thomas A, Thevis M, Mercer-Chalmers-Bender K. In vitro metabolic profiling of synthetic cannabinoids by pooled human liver microsomes, cytochrome P450 isoenzymes, and Cunninghamella elegans and their detection in urine samples Anal Bioanal Chem. 2019 Jun;411(16):3561-3579._x000D_ 6: Kobayashi K, Kajiwara E, Ishikawa M, Oka H, Chiba K. Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes Biopharm Drug Dispos. 2012 Nov;33(8):466-73._x000D_ 7: Madden S, Woolf TF, Pool WF, Park BK. An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes Biochem Pharmacol. 1993 Jul 6;46(1):13-20._x000D_ 8: Murayama N, Kaneko N, Horiuchi K, Ohyama K, Shimizu M, Ito K, Yamazaki H. Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies Drug Metab Pharmacokinet. 2009;24(4):404-8._x000D_ 9: Cho PJ, Kim JH, Lee HS, Kim JA, Lee S. Identification of specific UGT1A9-mediated glucuronidation of licoricidin in human liver microsomes Biopharm Drug Dispos. 2019 Feb;40(2):94-98._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/37263554">10: Lv X, Wang Z, Wang Z, Yin H, Xia Y, Jiang L, Liu Y. Drug-drug interaction potentials of tucatinib inhibition of human UDP-glucuronosyltransferases Chem Biol Interact. 2023 Aug 25;381:110574. </a>_x000D_ _x000D_ <strong>Products Related to Pooled Microsomes from Liver can be found at</strong> <a href="https://moleculardepot.com/product-category/Enzymes/"> Enzymes</a>