Pan-HCN-IN-1
Pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC50 of 58 nM. pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rats brain slices[1].
Product Specifications
CAS Number
[1334308-63-2]
UNSPSC
12352005
Target
HCN Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pan-hcn-in-1.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCOC1=CC=CC=C1C(NCC2(CCCCC2)N3CCN(CC3)C(C)C)=O
Molecular Formula
C23H37N3O2
Molecular Weight
387.56
References & Citations
[1]Harde E, et al., Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memory. Cell Chem Biol. 2024 Mar 21;31 (3) :577-592.e23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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