Z-IETD-FMK

Z-IETD-FMK (Z-IE (OMe) TD (OMe) -FMK) is a selective and cell permeable caspase-8 inhibitor[1]. Z-IETD-FMK is also a granzyme B inhibitor[5].

Product Specifications

CAS Number

[210344-98-2]

Product Name Alternative

Z-IE (OMe) TD (OMe) -FMK

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Z-IETD-FMK.html

Purity

98.0

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

COC(C[C@@H](C(CF)=O)NC([C@H]([C@H](O)C)NC([C@H](CCC(OC)=O)NC([C@H]([C@@H](C)CC)NC(OCC1=CC=CC=C1)=O)=O)=O)=O)=O

Molecular Formula

C30H43FN4O11

Molecular Weight

654.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Cowburn AS, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species.|[2]Lawrence CP, et al. Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties. Toxicol Appl Pharmacol. 2012 Nov 15;265 (1) :103-12.|[3]Tezel G, et al. Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro. Invest Ophthalmol Vis Sci. 1999 Oct;40 (11) :2660-7.|[4]Terlizzi M, et al. Pharmacological inhibition of caspase-8 limits lung tumour outgrowth. Br J Pharmacol. 2015 Aug;172 (15) :3917-28.|[5]Yang J, et al. Granzyme B Is an Essential Mediator in CD8+ T Cell Killing of Theileria parva-Infected Cells.Infect Immun. 2018 Dec 19;87 (1) . pii: e00386-18.