Z-IETD-FMK
Z-IETD-FMK (Z-IE (OMe) TD (OMe) -FMK) is a selective and cell permeable caspase-8 inhibitor[1]. Z-IETD-FMK is also a granzyme B inhibitor[5].
Product Specifications
CAS Number
210344-98-2
Product Name Alternative
Z-IE (OMe) TD (OMe) -FMK
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Z-IETD-FMK.html
Purity
98.0
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
COC(C[C@@H](C(CF)=O)NC([C@H]([C@H](O)C)NC([C@H](CCC(OC)=O)NC([C@H]([C@@H](C)CC)NC(OCC1=CC=CC=C1)=O)=O)=O)=O)=O
Molecular Formula
C30H43FN4O11
Molecular Weight
654.68
Precautions
H302, H315, H319, H335
References & Citations
[1]Cowburn AS, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species.|[2]Lawrence CP, et al. Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition properties. Toxicol Appl Pharmacol. 2012 Nov 15;265 (1) :103-12.|[3]Tezel G, et al. Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro. Invest Ophthalmol Vis Sci. 1999 Oct;40 (11) :2660-7.|[4]Terlizzi M, et al. Pharmacological inhibition of caspase-8 limits lung tumour outgrowth. Br J Pharmacol. 2015 Aug;172 (15) :3917-28.|[5]Yang J, et al. Granzyme B Is an Essential Mediator in CD8+ T Cell Killing of Theileria parva-Infected Cells.Infect Immun. 2018 Dec 19;87 (1) . pii: e00386-18.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 8
Available Sizes
Frequently Asked Questions
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