11 ß-HSD1 Double Nickase Plasmid

<strong>11 ß-HSD1 Double Nickase Plasmid</strong>_x000D_ <strong>Catalog number:</strong> B2015146_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ¬µg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8 ¬∞C_x000D_ <strong>Keywords:</strong> 11 ß-HSD1 Double Nickase Plasmid_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Tomlinson JW. 11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target Minerva Endocrinol. 2005 Mar;30(1):37-46._x000D_ 2: Yan H, Li X, Ni W, Zhao Q, Leng Y, Liu HY. Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 ß-HSD1 Enzyme Inhibitory Effects Chem Biodivers. 2021 Jan;18(1):e2000772._x000D_ 3: Lee NR, Kim BJ, Lee CH, Lee YB, Lee S, Hwang HJ, Kim E, Kim SH, Lee MG, Lee SE, Lavery GG, Choi EH. Role of 11 ß-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis Sci Rep. 2020 Nov 19;10(1):20237._x000D_ 4: Staab CA, Maser E. 11beta-Hydroxysteroid dehydrogenase type 1 is an important regulator at the interface of obesity and inflammation J Steroid Biochem Mol Biol. 2010 Mar;119(1-2):56-72._x000D_ 5: Osman DA, Mac√≠as MA, Al-Wahaibi LH, Al-Shaalan NH, Zondagh LS, Joubert J, Garcia-Granda S, El-Emam AA. Structural Insights and Docking Analysis of Adamantane-Linked 1,2,4-Triazole Derivatives as Potential 11 ß-HSD1 Inhibitors Molecules. 2021 Sep 2;26(17):5335._x000D_ 6: Chapman KE, Coutinho A, Gray M, Gilmour JS, Savill JS, Seckl JR. Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 and its role in the inflammatory response Ann N Y Acad Sci. 2006 Nov;1088:265-73._x000D_ 7: Hadoke PW, Kipari T, Seckl JR, Chapman KE. Modulation of 11 ß-hydroxysteroid dehydrogenase as a strategy to reduce vascular inflammation Curr Atheroscler Rep. 2013 May;15(5):320._x000D_ 8: Gathercole LL, Stewart PM. Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes J Steroid Biochem Mol Biol. 2010 Oct;122(1-3):21-7._x000D_ 9: Shao LD, Bao Y, Shen Y, Su J, Leng Y, Zhao QS. Synthesis of selective 11 ß-HSD1 inhibitors based on dammarane scaffold Eur J Med Chem. 2017 Jul 28;135:324-338._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/15519888">10: Seckl JR, Walker BR. 11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory Trends Endocrinol Metab. 2004 Nov;15(9):418-24. </a>_x000D_ _x000D_ <strong>Products Related to 11 ß-HSD1 Double Nickase Plasmid can be found at</strong> <a href="https://moleculardepot.com/product-category/DNA/"> DNA</a>