6-Methoxy-2-naphthoic acid

6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559) . 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E2. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds[1][2].

Product Specifications

CAS Number

[2471-70-7]

Product Name Alternative

6-MNA; Naproxen impurity O

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

COX; Drug Metabolite

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/6-Methoxy-2-naphthoic_acid.html

Purity

99.73

Solubility

DMSO : 60 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=CC=C2C=C(OC)C=CC2=C1)O

Molecular Formula

C12H10O3

Molecular Weight

202.21

Precautions

H315, H319, H335

References & Citations

[1]Cryer B, et al. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am J Med. 1998 May;104 (5) :413-21.|[2]Narayana B, et al. Synthesis of some new 2- (6-methoxy-2-naphthyl) - 5-aryl-1,3,4-oxadiazoles as possible non-steroidal anti-inflammatory and analgesic agents. Arch Pharm (Weinheim) . 2005 Aug;338 (8) :373-7.