(-) -Bicuculline (methobromide)

(-) -Bicuculline methobromide is a potent GABAA blocker. (-) -Bicuculline methobromide alters membrane properties and firing pattern. (-) -Bicuculline methobromide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. (-) -Bicuculline methobromide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1].

Product Specifications

CAS Number

[73604-30-5]

UNSPSC

12352005

Hazard Statement

H301, H311, H330, H400

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/minus-bicuculline-methobromide.html

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[N+]1(C)[C@@H]([C@H]2OC(C3=C4OCOC4=CC=C32)=O)C5=C(C=C6C(OCO6)=C5)CC1.[Br-]

Molecular Formula

C21H20BrNO6

Molecular Weight

462.29

Precautions

H301, H311, H330, H400

References & Citations

[1]Johnson SW, et al. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents. Neurosci Lett. 1997 Aug 1;231 (1) :13-6. |[2]Okazaki R, et al. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. Anesth Analg. 2008 Sep;107 (3) :1064-9.|[3]Sperber EF, et al. Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Brain Res. 1987 Dec 15;465 (1-2) :243-50. |[4]Yang Y, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression[J]. Nature, 2018, 554 (7692) : 317-322.