GW694590A
GW694590A (UNC10112731) is a MYC protein stabilizer that increases endogenous MYC protein levels. GW694590A also targets receptor tyrosine kinases, inhibiting DDR2, KIT and PDGFRα by 81% at 1 μM. , 68% and 67%. GW694590A is a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential effects on the Fluc reporter gene[1].
Product Specifications
CAS Number
948313-24-4
Product Name Alternative
UNC10112731
UNSPSC
12352005
Target
C-Kit; c-Myc; Discoidin Domain Receptor; PDGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gw694590a.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(OC2=CC3=C(NC(NC(OC)=O)=N3)C=C2)C=C1)NC4=CC=CC=C4
Molecular Formula
C22H19N5O4
Molecular Weight
417.42
References & Citations
[1]Blake DR, et al. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Sci Signal. 2019 Jul 16;12 (590) :eaav7259.|[2]Dranchak P, et al. Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays. PLoS One. 2013;8 (3) :e57888.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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