PDE4-IN-17
Product Specifications
UNSPSC Description
PDE4-IN-17 (compound 4e) is a potent PDE4 inhibitor. PDE4-IN-17 inhibits PDE4B and PDE4D with IC50s of 10.0 and 15.2 nM, respectively. PDE4-IN-17 has good oral bioavailability (F=66%) and longer half-life (t1/2=2.0 h) in SD rats[1].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde4-in-17.html
Smiles
O=C(CN1C=CN=C1)C2=CC=C(OC)C3=C2C=C(C4CC4)O3
Molecular Weight
296.32
References & Citations
[1]Xia C, et al. Discovery of 7-alkoxybenzofurans as PDE4 inhibitors with hepatoprotective activity in D-GalN/LPS-induced hepatic sepsis. Eur J Med Chem. 2024 Jun 7;275:116576.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162583/PDE4-IN-17-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162583/
Clinical Information
No Development Reported
Curated Selection
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