PPAR α (Phospho Ser21) rabbit pAb

Function: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. online information: Peroxisome proliferator-activated receptor entry, similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. similarity: Contains 1 nuclear receptor DNA-binding domain. subunit: Heterodimer with the retinoid X receptor. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Also interacts with PPARBP coactivator in vitro. Interacts with AKAP13. tissue specificity: Skeletal muscle, liver, heart and kidney.