Phospho-Stat6 (Tyr641) rabbit mAb PE conjugate Antibody
The transcription factor Stat6 is a member of the signal transducers and activators of transcription (STAT) family of proteins. Stat6 is the only member of this family that is activated by interleukin-4 (IL-4), after which Stat6 is both tyrosine- and serine-phosphorylated by Jak kinases. The consensus Stat6 binding site TTCN4GAA is found in the promoters of many genes regulated by IL-4. In T lymphocytes, Stat6 is required for differentiation into Th2 cells in response to IL-4. Stat6 may play a role in solid tumorigenesis; a large immunohistochemistry study of Stat6 expression in over 2,000 tumor samples confirmed strong nuclear staining.
Product Specifications
Product Name Alternative
Signal transducer and activator of transcription 6, IL-4 Stat
UniProt
P42226
Reactivity
Human, Mouse
Cross Reactivity
Predicted to work with mouse, rat and other homologues.
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6
Clonality
Monoclonal
Clone
BI34
Conjugation
FITC
Field of Research
Cancer Biology
Purification
Protein A+G
Dilution
Form
Liquid
Storage Conditions
2-8°C
Notes
For research use only.
Tested Applications
FC
Host or Source
Rabbit
Preservative
1X PBS, 0.09% NaN3, 0.2% rAlbumin
Isotype
Rabbit IgG1k
Available Sizes
Frequently Asked Questions
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