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Nicotinamide riboside (chloride)

Product Specifications

UNSPSC Description

Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].

Target Antigen

Endogenous Metabolite; Sirtuin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/nicotinamide-riboside-chloride.html

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic)|H2O : 125 mg/mL (ultrasonic)

Smiles

NC(C1=C[N+]([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)=CC=C1)=O.[Cl-]

Molecular Weight

290.703

References & Citations

[1]Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47.|[2]Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8.|[3]Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480.Basic Res Cardiol. 2024 Mar 25.|Curr Issues Mol Biol. 2024 Feb 1;46(2):1291-1307.|Exp Eye Res. 2024 Oct 15:248:110126.|Invest Ophthalmol Vis Sci. 2024 Jul 1;65(8):1.|Nat Commun. 2023 Jan 16;14(1):240.|Toxicol Appl Pharmacol. 2024 Aug 9:117066.|ACS Appl Mater Interfaces. 2024 Apr 16.|Cell Biosci. 2021 Nov 10;11(1):192.|Cells. 2023 Oct 2, 12(19), 2396.|Commun Biol. 2023 Mar 2;6(1):235.|FASEB J. 2022 Jul;36(7):e22418.|FASEB J. 2024 Apr 15;38(7):e23600.|Mol Ther. 2022 Sep 21;S1525-0016(22)00567-6.|Redox Biol. 2022 Oct 11;57:102507.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-123033A/Nicotinamide-riboside-chloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-123033A/Nicotinamide-riboside-chloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

23111-00-4

Available Sizes

Curated Selection

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