Phospho-MET (Tyr1234/1235) rabbit mAb Antibody

C-Met, also called tyrosine-protein kinase MET or hepatocyte growth factor receptor (HGFR), has tyrosine kinase activity (1) . MET is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing. Normally, MET is expressed only in stems cells and progenitor cells but excessive expression of MET/HGFR and its autocrine activation by co-expression of hepatocyte growth factor (HGF) ligand are implicated in oncogenesis (2,3) . Aberrantly activated MET leads to tumor growth, angiogenesis, and cancer metastasis and is correlated with poor prognosis. Abnormal activation of MET is observed in various human malignancies, such as kidney, liver, stomach, breast, and brain. MET activation by HGF induces MET kinase catalytic activity and leads to phosphorylation at Tyr 1234 and Tyr 1235.