Phospho-MKK3 (Ser189) /MKK6 (Ser207) rabbit mAb Antibody
MKK3 and MKK6 are closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5) . Phospho MKK3 and phospho MKK6 both phosphorylate and activate p38. p38 phosphorylation dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines (4,5) . Phospho MKK3 and phospho MKK6 activation occurs through phosphorylation at S189 and T222 on MKK3 (2) and S207 and T211 on MKK6 (4,5) .
Product Specifications
Product Name Alternative
UniProt
P46734
Reactivity
Human, Mouse
Cross Reactivity
Predicted to work with mouse, rat and other homologues.
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser189 of human phospho MKK3 and Ser207 of human phospho MKK6.
Clonality
Monoclonal
Clone
BF5
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Protein A+G
Concentration
0.5 mg/ml
Dilution
Form
Liquid
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
FC, WB
Host or Source
Rabbit
Preservative
1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% rAlbumin
Isotype
Rabbit IgG1k
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Cytokeratin, LMW (AE-1), CF405S conjugate, 0.1mg/mL
