Phospho-MKK3 (S189) /MKK6 (S207) rabbit mAb PE conjugate Antibody

MKK3 and MKK6 are closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5) . Phospho MKK3 and phospho MKK6 both phosphorylate and activate p38. p38 phosphorylation dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines (4,5) . Phospho MKK3 and phospho MKK6 activation occurs through phosphorylation at S189 and T222 on MKK3 (2) and S207 and T211 on MKK6 (4,5) .