Phospho-Stat1 (Ser727) rabbit mAb Antibody
Stat1 mediates the cellular response to IFNα, IFNB, and IFNg for the regulation of cell growth and the defense against viral and immune challenges. The Jak-Stat pathway plays a central role in the IFNg response, where Stat1 phosphorylation on Tyr701 causes homodimerization through its SH2 domain, translocation to the nucleus, and binding to gamma-activated sequence (GAS) elements. Early in the activation sequence, Stat1 is also phosphorylated at Ser727 through a mechanism involving PI3 kinase and Akt. Stat1 has been found to correlate with increased resistance to chemotherapeutic drugs. However, Stat1 activation of the immune system helps suppress tumor growth, and multiple melanomas and squamous-cell carcinomas have been known to downregulate Stat1 expression to evade immune surveillance.
Product Specifications
Product Name Alternative
Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84
UniProt
P42224
Reactivity
Human
Cross Reactivity
Predicted to work with mouse, rat, and other homologues.
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser727 of human phospho Stat1
Clonality
Monoclonal
Clone
BE8
Conjugation
Unconjugated
Field of Research
Infectious Disease & Virology
Purification
Protein A+G
Concentration
0.5 mg/mL
Dilution
Form
Liquid
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
FC, WB
Host or Source
Rabbit
Preservative
1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% rAlbumin
Isotype
Rabbit IgG1k
Available Sizes
Frequently Asked Questions
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