Phospho-NFkB p65 (Ser536) rabbit mAb Antibody
The nuclear factor kB (NFkB) /Rel family of transcription factors play a pivotal role in inflammatory and immune responses (1,2) . NF-kappa-B is present in almost all cell types and is involved in many biological processes including immunity, inflammation, cell growth and differentiation, apoptosis, and tumorigenesis. NFkB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFkB1/p105, NFkB1/p50, REL and NFkB2/p52. The dimers bind at kB sites in the target gene DNA. Individual dimers have distinct preferences for different kB sites and can act as either transcriptional activators or repressors. NFkB Ser536 phosphorylation stimulates Lys310 acetylation and interaction of phospho NFkB with CBP. Acetylated/phospho NFkB induces enhanced transcriptional activity.
Product Specifications
Product Name Alternative
Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, NFKB3
UniProt
Q04206
Reactivity
Human
Cross Reactivity
Predicted to work with mouse, rat and other homologues.
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser536 of human phospho NFkB.
Clonality
Monoclonal
Clone
BE0
Conjugation
Unconjugated
Field of Research
Signal Transduction
Purification
Protein A+G
Concentration
0.5 mg/mL
Dilution
Form
Liquid
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Preservative
1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% rAlbumin
Isotype
Rabbit IgG1k
Available Sizes
Frequently Asked Questions
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