Phospho-mTOR (Ser2448) rabbit mAb PE Conjugate Antibody

MTOR, m ammalian t arget o f r apamycin, is a Serine/Threonine protein kinase (1-2) that functions as an amino acid and ATP sensor to balance cell growth and nutrient availability (3-4) . When sufficient nutrients are available, mTOR transmits a positive signal to p70 S6 kinase and participates in the inactivation of 4E-BP1 (5) . mTOR plays a key role in homeostasis and cell growth, and phospho mTOR may be abnormally regulated in tumors. mTOR is a potential target for anti-cancer therapy (6) .