Phospho-MARCKS (Ser167/170) rabbit mAb APC conjugate Antibody
MARCKS (myristoylated alanine-rich C kinase substrate) is a major PKC substrate expressed in all eukaryotic cells (1,2) . It binds to and cross-links actin filaments to serve as a bridge between Ca2+/calmodulin and PKC signaling and attenuates phosphatidylinositol 4,5-bisphosphate plasma membrane signaling (3) . MARCKS is involved with cell mobility, phagocytosis, membrane traffic, cell adhesion, and mitogenesis. Ser159, 163, 167 and 170 of MARCKS are phosphorylated by PKC in response to cell groeth and cellular stress (4) . MARCKs phosphorylation is believe to induce its tranlocation from plasma membrane to cytoplasm.
Product Specifications
Product Name Alternative
Myristoylated alanine-rich C-kinase substrate, Protein kinase C substrate, PKCSL, 80 kDa protein light chain, MACS, PRKCSL
Reactivity
Human, Mouse, Rat
Cross Reactivity
Predicted to work with mouse, rat and other homologues.
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser167/170 of human phospho MARCKS
Clonality
Monoclonal
Clone
BE1
Conjugation
APC
Field of Research
Musculoskeletal & Connective Tissue Research
Purification
Protein A+G
Dilution
Form
Liquid
Storage Conditions
2-8°C
Notes
For research use only.
Tested Applications
FC
Host or Source
Rabbit
Preservative
1X PBS, 0.09% NaN3, 0.2% rAlbumin
Isotype
Rabbit IgG1k
Available Sizes
Frequently Asked Questions
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