COX-1-IN-1
COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC50s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC50/COX-1 IC50) is 217. COX-1-IN-1 inhibits platelet aggregation[1].
Product Specifications
CAS Number
1369503-03-6
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cox-1-in-1.html
Solubility
10 mM in DMSO
Smiles
CCOC1=CC=C(C2=NOC(C)=C2C3=CC=C(OCC)C=C3)C=C1
Molecular Formula
C20H21NO3
Molecular Weight
323.39
References & Citations
[1]Solidoro R, et al., A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior. Eur J Med Chem. 2024 Feb 15;266:116135.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
Frequently Asked Questions
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