SPR inhibitor 3

SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM) . SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels[1][2][3].

Product Specifications

CAS Number

[1292285-54-1]

Product Name Alternative

SPRi3

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/spr-inhibitor-3.html

Concentration

10mM

Purity

99.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCC1=C(C)NC2=C1C=C(O)C=C2)COC

Molecular Formula

C14H18N2O3

Molecular Weight

262.30

References & Citations

[1]Latremoliere A, et al. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. 2015 Jun 17;86 (6) :1393-406.|[2]Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563 (7732) :564-568.|[3]Haruki H, et al. Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid. J Biol Chem. 2016 Jan 8;291 (2) :652-7.