(3S,5S,6R) -Navtemadlin
(3S,5S,6R) -Navtemadlin is the isomer of Navtemadlin , and can be used as an experimental control. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].
Product Specifications
CAS Number
2459946-14-4
Product Name Alternative
(3S,5S,6R) -AMG 232; (3S,5S,6R) -KRT-232
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3s-5s-6r-navtemadlin.html
Purity
99.60
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C)S(C[C@@H](N1[C@@H](C2=CC=C(C=C2)Cl)[C@H](C3=CC(Cl)=CC=C3)C[C@](C)(C1=O)CC(O)=O)C(C)C)(=O)=O
Molecular Formula
C28H35Cl2NO5S
Molecular Weight
568.55
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Eosinophil Peroxidase (AHE-1), CF405S conjugate, 0.1mg/mL
P27 / KIP1 (SX53G8), CF405S conjugate, 0.1mg/mL
TGF-beta (1D11.16.8), CF568 conjugate, 0.1mg/mL
