(3S,5S,6R) -Navtemadlin

(3S,5S,6R) -Navtemadlin is the isomer of Navtemadlin (HY-12296), and can be used as an experimental control. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].

Product Specifications

CAS Number

[2459946-14-4]

Product Name Alternative

(3S,5S,6R) -AMG 232; (3S,5S,6R) -KRT-232

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3s-5s-6r-navtemadlin.html

Purity

99.60

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(C)S(C[C@@H](N1[C@@H](C2=CC=C(C=C2)Cl)[C@H](C3=CC(Cl)=CC=C3)C[C@](C)(C1=O)CC(O)=O)C(C)C)(=O)=O

Molecular Formula

C28H35Cl2NO5S

Molecular Weight

568.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Canon J, et al. The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents. Mol Cancer Ther. 2015 Mar;14 (3) :649-58.|[2]Rew Y, et al. Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57 (15) :6332-41.