PROTAC YAP degrader-1

PROTAC YAP degrader-1 (compound YZ-6) is a PROTAC targeting YAP and also inhibits the nuclear localization of YAP. PROTAC YAP degrader-1 is composed of PROTAC target protein ligand NSC682769 (HY-168017) (red part) and E3 ubiquitin ligase ligand + Linker conjugate (R, S, R) -AHPC-PEG2-C2-boc (HY-168019) (blue+black part), in which the PROTAC Linker used is Acid-PEG2-C2-Boc (HY-140480) and the target protein ligand activity control is Demethyl-NSC682769 (HY-168018) [1].

Product Specifications

CAS Number

[3058483-58-9]

UNSPSC

12352005

Target

PROTACs; YAP

Type

Reference compound

Related Pathways

PROTAC; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-yap-degrader-1.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCOCCOCCOC4=CC=C(C=C4OC)C5=C(C(C6=CC=CC=C6N7)=NC(C8=CC=CC=C8)=C5)CC7=O)=O)=O

Molecular Formula

C56H62N6O9S

Molecular Weight

995.19

References & Citations

[1]Zhou C, et al. Exploring Degradation of Intrinsically Disordered Protein Yes-Associated Protein Induced by Proteolysis TArgeting Chimeras. J Med Chem. 2024 Sep 12;67 (17) :15168-15198.