PtdIns- (3,4,5) -P3-biotin (sodium)
PtdIns- (3,4,5) -P3-biotin sodium is a Biotin-labeled PtdIns- (3,4,5) -P3 (PI (3,4,5) P3) . PI (3,4,5) P3 is a substrate of nuclear phosphatidylinositol 5-phosphatase (PIP5Pase) . PI (3,4,5) P3 binds to the N-terminus of RAP1 (repressor activator protein 1) and controls its DNA binding activity[1].
Product Specifications
CAS Number
[1415684-80-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ptdins-3-4-5-p3-biotin-sodium.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=P(O)(O[Na])O[C@H]1[C@@H]([C@H]([C@@H]([C@@H]([C@@H]1OP(O)(O[Na])=O)O)OP(OC[C@@H](COC(CCCCCCCNC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O)OC(CCCCCCC)=O)(O[Na])=O)O)OP(O)(O[Na])=O
Molecular Formula
C35H61N3Na4O24P4S
Molecular Weight
1155.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Touray AO, et al. PI (3,4,5) P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes. Elife. 2023 Nov 29;12:RP89331.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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