YCW-E11

YCW-E11 is a Bcl-2, and Mcl-1 inhibitor with Ki values of 0.83 and 0.33 μM, respectively. YCW-E11 induces cell apoptosis through the mitochondrial pathway and exhibits antitumor activity. YCW-E11 can be utilized in cancer research[1].

Product Specifications

CAS Number

[1519043-97-0]

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ycw-e11.html

Smiles

O=C(NCCNS(=O)(C1=C(C2=C(OC3=CC=C(C(O)=C3)O)C=CC=C2)C=CS1)=O)NC4=CC(Cl)=CC(Cl)=C4

Molecular Formula

C25H21Cl2N3O6S2

Molecular Weight

594.49

References & Citations

[1]Yang C, et al. Development of 3-phenyl-N- (2- (3-phenylureido) ethyl) -thiophene-2-sulfonamide compounds as inhibitors of antiapoptotic Bcl-2 family proteins. ChemMedChem. 2014 Jul;9 (7) :1436-52.