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Gaultherin (Standard)

Gaultherin (Standard) is the analytical standard for Gaultherin (HY-N1965) . Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, COX-2 (IC50 = 0.35 mg/mL), LOX (IC50 = 0.56 mg/mL) and HYAL (IC50 = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654) [1][2].

Product Specifications

CAS Number

[490-67-5]

UNSPSC

12352005

Target

COX; Interleukin Related; MMP; Monoamine Oxidase; NF-κB; p38 MAPK; Reactive Oxygen Species (ROS) ; Reference Standards; TNF Receptor

Type

Reference Standards

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gaultherin-standard.html

Smiles

COC(C1=C(C=CC=C1)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO[C@H]3[C@@H]([C@H]([C@@H](CO3)O)O)O)=O

Molecular Formula

C19H26O12

Molecular Weight

446.40

References & Citations

[1]Zhang B, et, al. Gaultherin, a natural salicylate derivative from Gaultheria yunnanensis: towards a better non-steroidal anti-inflammatory drug. Eur J Pharmacol. 2006 Jan 13;530 (1-2) :166-71.|[2]Michel P. Gaultherin, a Natural Alternative to Aspirin: A Comprehensive Review of Molecular Mechanisms, Pharmacokinetics, Biocompatibility, Isolation Techniques, and Plant Sources. Int J Mol Sci. 2025 Jul 28;26 (15) :7280.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Curated Selection

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