PERK/eIF2α activator 1

PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC50 value of 23 μM[1].

Product Specifications

CAS Number

[1178583-17-9]

UNSPSC

12352005

Target

Apoptosis; PERK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/perk-eif2α-activator-1.html

Purity

98.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=CC=C2)OC3=C(C(OCCCCN(CCO)CCO)=CC(O)=C13)OC

Molecular Formula

C24H29NO7

Molecular Weight

443.49

References & Citations

[1]Yi Zhang, et al. V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. Arch Toxicol. 2014, 88, 1.