Ac-RLR-AMC (TFA)
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm) . AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes[1].
Product Specifications
Product Name Alternative
Ac-Arg-Leu-Arg-AMC (TFA)
UNSPSC
12352209
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ac-rlr-amc-tfa.html
Smiles
O=C(O)C(F)(F)F.CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)=O)C=C1O2)=CC2=O.[x]
Molecular Formula
C30H46N10O6.xCF3COOH
Molecular Weight
642.8 (free base)
References & Citations
[1]Chang TL. Inhibitory effect of flavonoids on 26S proteasome activity. J Agric Food Chem. 2009 Oct 28;57 (20) :9706-15.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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