Promazine (hydrochloride)

Promazine (Romtiazin) hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist. Promazine hydrochloride inhibits dopaminergic neurotransmission[1][2].

Product Specifications

CAS Number

[53-60-1]

Product Name Alternative

Romtiazin (hydrochloride) ; Ampazine (hydrochloride) ; Berophen (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H317

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Promazine-hydrochloride.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=CC=C13.[H]Cl

Molecular Formula

C17H21ClN2S

Molecular Weight

320.88

Precautions

H302, H317

References & Citations

[1]Gareri P, et al. Conventional and atypical antipsychotics in the elderly : a review. Clin Drug Investig. 2003;23 (5) :287-322. |[2]Myers PR, et al. Characterization of a depolarizing dopamine response in a vertebrate neuronal somatic cell hybrid. J Cell Physiol. 1977;91 (1) :103-118. |[3]Tatsumi M, et al. Pharmacological profile of neuroleptics at human monoamine transporters. Eur J Pharmacol. 1999;368 (2-3) :277-283.