Spadin (TFA)
Product Specifications
UNSPSC Description
Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin TFA can be used for antidepressant research[1][2].
Target Antigen
5-HT Receptor; Potassium Channel
Type
Peptides
Related Pathways
GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/spadin-tfa.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)
Smiles
N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CO)NC([C@H](C(C)C)NC(CNC([C@H]([C@@H](C)CC)NC([C@H]3N(C(CNC([C@H](CO)NC([C@H](CC4=CNC5=CC=CC=C45)NC([C@H](CCCNC(N)=N)NC([C@H]6N(C([C@H](CC(C)C)NC([C@H]7N(C([C@H](C)NC([C@H](CC8=CC=C(C=C8)O)N)=O)=O)CCC7)=O)=O)CCC6)=O)=O)=O)=O)=O)CCC3)=O)=O)=O)=O)=O)=O)=O)=O.FC(F)(F)C(O)=O
Molecular Weight
2126.36
References & Citations
[1]Borsotto M, et, al. Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br J Pharmacol. 2015 Feb;172(3):771-84. |[2]Mazella J, et, al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1422A/Spadin-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1422A/Spadin-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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