Spadin (TFA)

Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin TFA can be used for antidepressant research[1][2].

Product Specifications

UNSPSC

12352209

Target

5-HT Receptor; Potassium Channel

Type

Peptides

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/spadin-tfa.html

Purity

99.73

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CO)NC([C@H](C(C)C)NC(CNC([C@H]([C@@H](C)CC)NC([C@H]3N(C(CNC([C@H](CO)NC([C@H](CC4=CNC5=CC=CC=C45)NC([C@H](CCCNC(N)=N)NC([C@H]6N(C([C@H](CC(C)C)NC([C@H]7N(C([C@H](C)NC([C@H](CC8=CC=C(C=C8)O)N)=O)=O)CCC7)=O)=O)CCC6)=O)=O)=O)=O)=O)CCC3)=O)=O)=O)=O)=O)=O)=O)=O.FC(F)(F)C(O)=O

Molecular Formula

C92H143F3N26O24

Molecular Weight

2126.36

References & Citations

[1]Borsotto M, et, al. Targeting two-pore domain K (+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br J Pharmacol. 2015 Feb;172 (3) :771-84. |[2]Mazella J, et, al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8 (4) :e1000355.