Mizagliflozin (sebacate)
Mizagliflozin sebacate (DSP-3235 sebacate) is a sodium-glucose cotransporter inhibitor with activity in improving vascular cognitive impairment caused by small vessel disease. Mizagliflozin sebacate improves blood flow and reverses vascular cognitive impairment by inhibiting neuronal SGLT1 activity. Mizagliflozin sebacate also showed the ability to increase the survival rate of IL-1β-treated PC12HS cells. Mizagliflozin sebacate promotes improvements in spatial learning and memory caused by small vessel disease in mouse models[1].
Product Specifications
CAS Number
1169392-27-1
Product Name Alternative
DSP-3235 (sebacate) ; KGA-3235 (sebacate) ; GSK-1614235 (sebacate)
UNSPSC
12352005
Target
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mizagliflozin-sebacate.html
Smiles
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=NNC(C(C)C)=C2CC3=C(C=C(C=C3)OCCCNCC(C)(C)C(N)=O)C.OC(CCCCCCCCC(O)=O)=O.[0.5]
Molecular Formula
C28H44N4O8.1/2C10H18O4
Molecular Weight
1331.59
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
SGLT1
Frequently Asked Questions
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