NPAS3-IN-1
NPAS3-IN-1 is a potent inhibitor of NPAS3-ARNT heterodimerization and regulates NPAS3 transcription by disrupting the heterodimerization of NPAS3 with ARNT at the cellular level[1].
Product Specifications
CAS Number
[2207-44-5]
UNSPSC
12352005
Hazard Statement
H302
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/npas3-in-1.html
Purity
98.29
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=[N+](C1=CN=C(SC2=NC3=CC=CC=C3S2)S1)[O-]
Molecular Formula
C10H5N3O2S3
Molecular Weight
295.36
Precautions
P264-P270-P330-P501
References & Citations
[1]Li P, et al. Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT. Bioorg Chem. 2023 Oct;139:106676.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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