Hydroxyzine (pamoate)

Hydroxyzine pamoate is a histamine receptor H1 antagonist, one of the salt forms of Hydroxyzine, soluble in dimethyl formamide and chloroform but insoluble in water and alcohol[1].

Product Specifications

CAS Number

[10246-75-0]

UNSPSC

12352005

Hazard Statement

H302

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Hydroxyzine-pamoate.html

Purity

99.85

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=C(O)C(CC2=C3C=CC=CC3=CC(C(O)=O)=C2O)=C4C=CC=CC4=C1)O.ClC5=CC=C(C(N6CCN(CCOCCO)CC6)C7=CC=CC=C7)C=C5

Molecular Formula

C44H43ClN2O8

Molecular Weight

763.27

Precautions

H302

References & Citations

[1]C T King, et al. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am J Obstet Gynecol. 1966 May 1;95 (1) :109-11.|[2]Tadiboyina Sirisha, et al. Enantioselective UFLC Determination of Hydroxyzine Enantiomers and Application to a Pharmacokinetic Study in Rabbits. J Chromatogr Sci. 2016 Nov;54 (10) :1806-1812.|[3]Loyd V, et al. Hydroxyzine Pamoate 5 mg/mL Oral Suspension. US Pharm. 2014;39 (5) :57-58.|[4]Petra Bizikova, et al. Blackwell Publishing Ltd Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs. Vet Dermatol. 1966 May 1;95 (1) :109-11.|[5]J L Barbet, et al. Duration of inhibition of immediate skin test reactivity by hydroxyzine hydrochloride in dogs. J Am Vet Med Assoc. 1989 Jun 1;194 (11) :1565-9.