Anti-Tau Antibody

Mouse Monoclonal Antibody specific to Tau

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau

Gene Name

MAPT

NCBI Gene ID

UniProt

P10636

Cellular Locus

Cytoplasm, cytosol, Cell membrane, Cytoplasm, cytoskeleton, Cell projection, axon, Cell projection, dendrite, Secreted

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Full-length recombinant human Tau441 (2N4R) P301S mutant protein pre-formed fibrils. In humans, mutation P301S gives rise to early-onset dementia.

Target Antigen

Microtubule-associated protein tau

Target

Tau

Clonality

Monoclonal

Type

Antibody

Applications

WB, DB, ICC/IF, ELISA

Purification Method

Purified by Protein G affinity chromatography

Concentration

1.0 mg/mL

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {PubMed:21985311, PubMed:32961270}.