Rostafuroxin
Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+, K+-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV) -triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity[1][2][3][4].
Product Specifications
CAS Number
[156722-18-8]
Product Name Alternative
PST 2238
UNSPSC
12352005
Target
Na+/K+ ATPase; RSV
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Rostafuroxin.html
Concentration
10mM
Purity
99.03
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O)C1)C)([H])[C@]2([H])CC3)(CC[C@@]4(C5=COC=C5)O)[C@]34C
Molecular Formula
C23H34O4
Molecular Weight
374.51
References & Citations
++++
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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