Prostaglandin D2

Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

Product Specifications

CAS Number

[41598-07-6]

Product Name Alternative

PGD2

UNSPSC

12352211

Hazard Statement

H302, H361

Target

Endogenous Metabolite; Prostaglandin Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Prostaglandin_D2.html

Purity

99.5

Solubility

Ethanol : 75 mg/mL (ultrasonic; warming)

Smiles

CCCCC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H](O)CC1=O)C/C=C\CCCC(O)=O

Molecular Formula

C20H32O5

Molecular Weight

352.47

Precautions

H302, H361

References & Citations

[1]Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385 (2) :321-8.|[2]Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38 (4) :469-476.|[3]Kida T, et al. Prostaglandin D2 Attenuates NSC 125066-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11 (12) :e0167729.