PROTAC Bcl-xL degrader-3
PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader (WO2020163823A2, compound 44) [1].
Product Specifications
CAS Number
2471970-60-0
UNSPSC
12352005
Target
Bcl-2 Family; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-bcl-xl-degrader-3.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCCCC(N(CC4)CCN4C[C@@](C)(C5)CCC(C6=CC=C(C=C6)Cl)=C5CN7CCN(C8=CC=C(C=C8)C(NS(=O)(C9=CC(S(C(F)(F)F)(=O)=O)=C(C=C9)N[C@@H](CSC%10=CC=CC=C%10)CCN%11CCOCC%11)=O)=O)CC7)=O)=O
Molecular Formula
C82H105ClF3N11O11S4
Molecular Weight
1641.49
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-xL; von Hippel-Lindau (VHL)
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