Human LAG-3 Extracellular Domain

<strong>Human LAG-3 Extracellular Domain</strong>_x000D_ <strong>Catalog number:</strong> B2017224_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 47 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> CD223, Lymphocyte Activation Gene 3 Protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Xiao Q, Li X, Li Y, Wu Z, Xu C, Chen Z, He W. Biological drug and drug delivery-mediated immunotherapy Acta Pharm Sin B. 2021 Apr;11(4):941-960._x000D_ 2: Kano Y, Iguchi T, Matsui H, Adachi K, Sakoda Y, Miyakawa T, Doi S, Hazama S, Nagano H, Ueyama Y, Tamada K. Combined adjuvants of poly(I:C) plus LAG-3-Ig improve antitumor effects of tumor-specific T cells, preventing their exhaustion Cancer Sci. 2016 Apr;107(4):398-406._x000D_ 3: Wang C, Lai AY, Baiu DC, Smith KA, Odorico JS, Wilson K, Schreiber T, de Silva S, Gumperz JE. Analysis of Butyrophilin-Mediated Activation of γδ T Cells from Human Spleen J Immunol. 2024 Jan 15;212(2):284-294._x000D_ 4: Huard B, Prigent P, Pagès F, Bruniquel D, Triebel F. T cell major histocompatibility complex class II molecules down-regulate CD4+ T cell clone responses following LAG-3 binding Eur J Immunol. 1996 May;26(5):1180-6._x000D_ 5: Jeon S, Kim TK, Jeong SJ, Jung IH, Kim N, Lee MN, Sonn SK, Seo S, Jin J, Kweon HY, Kim S, Shim D, Park YM, Lee SH, Kim KW, Cybulsky MI, Shim H, Roh TY, Park WY, Lee HO, Choi JH, Park SH, Oh GT. Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis Circulation. 2020 Nov 3;142(18):1736-1751._x000D_ 6: Weerasinghe-Mudiyanselage PDE, Kim J, Choi Y, Moon C, Shin T, Ahn M. Ninjurin-1: a biomarker for reflecting the process of neuroinflammation after spinal cord injury Neural Regen Res. 2021 Jul;16(7):1331-1335._x000D_ 7: Shi Y, Liu Y, Wu C, Liu X, Hu W, Yang Z, Li Z, Li Y, Deng C, Wei K, Gu C, Chen X, Su W, Zhuo Y. N,N-Dimethyl-3β-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia/reperfusion injury by inhibiting Ninjurin 1 J Neuroinflammation. 2023 Apr 7;20(1):91._x000D_ 8: Pandey A, Shen C, Feng S, Man SM. Cell biology of inflammasome activation Trends Cell Biol. 2021 Nov;31(11):924-939._x000D_ 9: Dong N, Wu X, Hong T, Shen X, Guo X, Wang H, Yu L, Zhao H, Fang Q. Elevated Serum Ninjurin-1 Is Associated with a High Risk of Large Artery Atherosclerotic Acute Ischemic Stroke Transl Stroke Res. 2023 Aug;14(4):465-471._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/37798443">10: den Hartigh AB, Loomis WP, Anderson MJ, Frølund B, Fink SL. Muscimol inhibits plasma membrane rupture and ninjurin-1 oligomerization during pyroptosis Commun Biol. 2023 Oct 5;6(1):1010. </a>_x000D_ _x000D_ <strong>Products Related to Human LAG-3 Extracellular Domain can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>