VEGFR-2-IN-46

VEGFR-2-IN-46 (compound 4d) is a potent VEGFR-2 inhibitor with an EC50 value of 67.0 nM. VEGFR-2-IN-46 shows cytotoxicity and induces cell cycle arrest at the G2/M phase. VEGFR-2-IN-46 induces necrosis and apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Necroptosis; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-in-46.html

Smiles

O=C(C1=CC=C(OC)C=C1)CSC2=NN=C(O2)C3=CC=CC(OC4=CC=CC=C4)=C3

Molecular Formula

C23H18N2O4S

Molecular Weight

418.47

References & Citations

[1]Heriz MH, et al. Synthesis, docking study, and antitumor evaluation of benzamides and oxadiazole derivatives of 3-phenoxybenzoic acid as VEGFR-2 inhibitors. Drug Dev Res. 2024 May;85 (3) :e22186.