VEGFR-2-IN-46
Product Specifications
UNSPSC Description
VEGFR-2-IN-46 (compound 4d) is a potent VEGFR-2 inhibitor with an EC50 value of 67.0 nM. VEGFR-2-IN-46 shows cytotoxicity and induces cell cycle arrest at the G2/M phase. VEGFR-2-IN-46 induces necrosis and apoptosis[1].
Target Antigen
Apoptosis; Necroptosis; VEGFR
Type
Reference compound
Related Pathways
Apoptosis;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-46.html
Smiles
O=C(C1=CC=C(OC)C=C1)CSC2=NN=C(O2)C3=CC=CC(OC4=CC=CC=C4)=C3
Molecular Weight
418.47
References & Citations
[1]Heriz MH, et al. Synthesis, docking study, and antitumor evaluation of benzamides and oxadiazole derivatives of 3-phenoxybenzoic acid as VEGFR-2 inhibitors. Drug Dev Res. 2024 May;85(3):e22186.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163740/VEGFR-2-IN-46-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163740/
Clinical Information
No Development Reported
Curated Selection
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