SDZ-MKS 492
Product Specifications
UNSPSC Description
SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats[1].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sdz-mks-492.html
Purity
99.77
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(N1C)N(C)C2=C(N(CCOC)C(N[C@H](C3=CC=C(OC)C(OC)=C3)CO)=N2)C1=O
Molecular Weight
433.46
References & Citations
[1]Nagai H, et al. Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats. Jpn J Pharmacol. 1993 Dec;63(4):405-13.|[2]Morley J, et, al. SDZ MKS 492. Agents Actions Suppl. 1991;34:403-10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100164/SDZ-MKS-492-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100164/SDZ-MKS-492-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
114606-56-3
Available Sizes
Curated Selection
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