SDZ-MKS 492

SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE) . SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF) -induced bronchoconstriction and allergic reactions in guinea pigs and rats[1].

Product Specifications

CAS Number

[114606-56-3]

Product Name Alternative

MKS 492

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sdz-mks-492.html

Purity

99.77

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(N1C)N(C)C2=C(N(CCOC)C(N[C@H](C3=CC=C(OC)C(OC)=C3)CO)=N2)C1=O

Molecular Formula

C20H27N5O6

Molecular Weight

433.46

References & Citations

[1]Nagai H, et al. Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats. Jpn J Pharmacol. 1993 Dec;63 (4) :405-13.|[2]Morley J, et, al. SDZ MKS 492. Agents Actions Suppl. 1991;34:403-10.