Rolapitant
Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model[1][2].
Product Specifications
CAS Number
552292-08-7
Product Name Alternative
SCH619734
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Rolapitant.html
Purity
99.89
Solubility
DMSO : ≥ 30 mg/mL
Smiles
C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)OC[C@@]2(C3=CC=CC=C3)CC[C@@]4(NC(CC4)=O)CN2
Molecular Formula
C25H26F6N2O2
Molecular Weight
500.48
Precautions
H315, H319, H320
References & Citations
[1]Duffy RA, et al. Rolapitant (SCH 619734) : a potent, selective and orally active neurokininNK1 receptor antagonist with centrally-mediated antiemetic effects inferrets. Pharmacol Biochem Behav. 2012 Jul;102 (1) :95-100.|[2]Rapoport B, et al. Study of rolapitant, a novel, long-acting, NK-1 receptor antagonist, for the prevention of chemotherapy-induced nausea and vomiting (CINV) due to highly emetogenic chemotherapy (HEC) . Support Care Cancer. 2015 Nov;23 (11) :3281-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
NK1R
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
bs-2780R-PerCP 100 µL
CD44v10 Polyclonal Antibody, PerCP Conjugated
Sign In for Pricing
View Details K6190202 1.0 µg DNA
Thsd7b sgRNA CRISPR Lentivector (Rat) (Target 1)
Sign In for Pricing
View Details