Dyrk1A-IN-7
Dyrk1a-in-7 (Compound 29) is a selective DYRK1A kinase inhibitor, and has good kinase selectivity for CLK1 kinase. The IC50 value of DYRK1A is 28 nM. For CLK2, Kd is 17.5 nM. Dyrk1a-in-7 can be used in the research of cancer, type II diabetes and neurological diseases[1].
Product Specifications
UNSPSC
12352005
Target
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dyrk1a-in-7.html
Solubility
10 mM in DMSO
Smiles
CC1=C(N2N=C(C=CC2=N1)C3=CC=NC=C3)C4=CC(OC(F)(F)F)=CC=C4
Molecular Formula
C19H13F3N4O
Molecular Weight
370.33
References & Citations
[1]Scott H, et al. Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases. European Journal of Medicinal Chemistry. 269 (2024) 116292.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1
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