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IL-27R alpha/TCCR, Human (HEK293, Fc)

IL-27R alpha (Interleukin 27 receptor alpha) is a subunit of the interleukin-27 receptor, an inflammatory cytokine that possesses extensive immunological functions. IL-27R alphacan be used as a natural IL-27 antagonist[1]. IL-27R alpha/TCCR Protein, Human (HEK293, Fc) is a recombinant protein with a Fc label that is produced by HEK293 cells.

Product Specifications

Product Name Alternative

IL-27R alpha/TCCR Protein, Human (HEK293, Fc), Human, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/il-27r-alpha-tccr-protein-human-514a-a-hek293-fc.html

Purity

95

Molecular Formula

9466 (Gene_ID) Q6UWB1 (Q33-R514) (Accession)

Molecular Weight

Approximately 105-115 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

References & Citations

[1]Liu S, et al. Soluble interleukin-27 receptor alpha is a valuable prognostic biomarker for acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation. Sci Rep. 2018 Jul 9;8 (1) :10328.|[2]Fabbi M, et al. Dual Roles of IL-27 in Cancer Biology and Immunotherapy. Mediators Inflamm. 2017;2017:3958069.|[3]Rousseau F, et al. IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants. Proc Natl Acad Sci U S A. 2010 Nov 9;107 (45) :19420-5.|[4]Miyazaki Y, et al. Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice. J Immunol. 2005 Aug 15;175 (4) :2401-7.|[5]Lo HC, et al. IL-27/IL-27RA signaling may modulate inflammation and progression of benign prostatic hyperplasia via suppressing the LPS/TLR4 pathway. Transl Cancer Res. 2020 Aug;9 (8) :4618-4634.

Shipping Conditions

Dry ice

Storage Conditions

Stored at -80°C for 1 year

Scientific Category

Recombinant Proteins

Available Sizes

Frequently Asked Questions

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