2-Oleoylglycerol

2-Oleoylglycerol (2-OG) is a lipid found in the diet. It is a GPR119 agonist, with an EC50 value of 2.5 μM in activating hGPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol enhances the inflammatory response of macrophages and promotes fibrosis by activating the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. It also stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol is expected to be used in the research of non-alcoholic steatohepatitis (NASH) [1][2][3].

Product Specifications

CAS Number

[3443-84-3]

Product Name Alternative

2-OG

UNSPSC

12352211

Hazard Statement

H225, H319

Target

GLP Receptor; GPR119; NF-κB; TGF-beta/Smad

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling; NF-κB; Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-oleoylglycerol.html

Concentration

28 mM * 100 μL in Ethanol

Purity

99.0

Solubility

10 mM in DMSO

Smiles

OCC(CO)OC(CCCCCCC/C=C\CCCCCCCC)=O

Molecular Formula

C21H40O4

Molecular Weight

356.55

Precautions

H225, H319

References & Citations

[1]Hansen KB, et, al. 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metab. 2011 Sep;96 (9) :E1409-17.|[2]Ghafouri N, et, al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol. 2004 Nov;143 (6) :774-84.|[3]Yang M, et al. Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol. Nat Commun. 2023 Jan 16;14 (1) :228.